Welcome to issue 23 of PERTinent Updates, featuring a select group of articles for your review. We aim to inform and update our members with the most recent major developments in the fields of PERT/VTE so that we in the PERT Consortium™ can continue to be at the leading edge of improving care for this vulnerable and overlooked group of patients.

Issue Highlight:
From Our Own

PERT is honored to be mentioned in the newly released European Guidelines for the diagnosis and management of acute PE.

• 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS).

Guidelines/Scientific Statements

2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS).
Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola VP, Huisman MV, Humbert M, Jennings CS, Jiménez D, Kucher N, Lang IM, Lankeit M, Lorusso R, Mazzolai L, Meneveau N, Ní Áinle F, Prandoni P, Pruszczyk P, Righini M, Torbicki A, Van Belle E, Zamorano JL; ESC Scientific Document Group .
Eur Heart J. 2019 Aug 31. pii: ehz405. [Epub ahead of print].
PMID: 31504429

Interventional Therapies for Acute Pulmonary Embolism: Current Status and Principles for the Development of Novel Evidence: A Scientific Statement From the American Heart Association.
Giri J, Sista AK, Weinberg I, Kearon C, Kumbhani DJ, Desai ND, Piazza G, Gladwin MT, Chatterjee S, Kobayashi T, Kabrhel C, Barnes GD; American Heart Association Council on Peripheral Vascular Disease; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; and Council on Cardiovascular Surgery and Anesthesia.
Circulation. 2019 Oct 4. [Epub ahead of print]
PMID: 31585051

Diagnostic Testing/Risk Stratification

Usefulness of standard computed tomography pulmonary angiography performed for acute pulmonary embolism for identification of chronic thromboembolic pulmonary hypertension: results of the InShape III study.
Ende-Verhaar YM, Meijboom LJ, Kroft LJM, Beenen LFM, Boon GJAM, Middeldorp S, Nossent EJ, Symersky P, Huisman MV, Bogaard HJ, Noordegraaf AV, Klok FA.
J Heart Lung Transplant. 2019 Mar 15. pii: S1053-2498(19)31424-X.
doi: 10.1016/j.healun.2019.03.003. [Epub ahead of print]
PMID: 30962147

Could the YEARS algorithm be used to exclude pulmonary embolism during pregnancy? Data from the CT-PE-pregnancy study.
Langlois E, Cusson-Dufour C, Moumneh T, Elias A, Meyer G, Lacut K, Schmidt J, Le Gall C, Chauleur C, Glauser F, Robert-Ebadi H, Righini M, Le Gal G.
J Thromb Haemost. 2019 May 20. 3
doi: 10.1111/jth.14483. [Epub ahead of print]
PMID: 31108013

Therapy Related

Pharmacotherapy

Apixaban and Dalteparin in Active Malignancy Associated Venous Thromboembolism: The ADAM VTETrial.
McBane R 2nd, Wysokinski WE, Le-Rademacher JG, Zemla T, Ashrani A, Tafur A, Perepu U, Anderson D, Gundabolu K, Kuzma C, Perez Botero J, Leon Ferre RA, Henkin S, Lenz CJ, Houghton DE, Vishnu P, Loprinzi CL.
J Thromb Haemost. 2019 Oct 20. doi: 10.1111/jth.14662. [Epub ahead of print]

IVC Filters

Effectiveness of Inferior Vena Cava Filters in Patients with Stable and Unstable Pulmonary Embolism and Trends in Their Use.
Stein PD, Matta F, Hughes MJ.
Am J Med. 2019 Sep 11. pii: S0002-9343(19)30754-5. [Epub ahead of print]PMID: 31520620

Review

Meta-Analysis of Catheter Directed Ultrasound-Assisted Thrombolysis in Pulmonary Embolism.
Pei DT, Liu J, Yaqoob M, Ahmad W, Bandeali SS, Hamzeh IR, Virani SS, Hira RS, Lakkis NM, Alam M.
Am J Cardiol. 2019 Nov 1;124(9):1470-1477. Epub 2019 Aug 7. Review.
PMID: 31492420

Upcoming Studies

Validation and impact of a simplified clinical decision rule for diagnosing pulmonary embolism in primary care: design of the PECAN prospective diagnostic cohort management study.
van Maanen R, Rutten FH, Klok FA, Huisman MV, Blom JW, Moons KGM, Geersing GJ.
BMJ Open. 2019 Oct 10;9(10):e031639. doi: 10.1136/bmjopen-2019-031639.
PMID: 31601598

From Our Own…

A narrative review of red blood cell distribution width as a marker for pulmonary embolism.
Hammons L, Filopei J, Steiger D, Bondarsky E.
J Thromb Thrombolysis. 2019 Nov;48(4):638-647. Review.
PMID: 31228037

Analysis of Partial Thromboplastin Times in Patients with Pulmonary Embolism During the First 48 Hours of Anticoagulation with Unfractionated Heparin.
Prucnal CK, Jansson PS, Deadmon E, Rosovsky RP, Zheng H, Kabrhel C.
Acad Emerg Med. 2019 Oct 18. [Epub ahead of print]
PMID: 31625654

Pulmonary Embolism Response Teams: Pursuing Excellence in the Care for Venous Thromboembolism.
Porres-Aguilar M, Anaya-Ayala JE, Jiménez D, Mukherjee D.
Arch Med Res. 2019 Oct 5;50(5):257-258. [Epub ahead of print]
PMID:31593849

Impact of Multidisciplinary Pulmonary Embolism Response Team Availability on Management and Outcomes.
Chaudhury P, Gadre S, Schneider E, Renapurkar R, Gomes M, Haddadin I, Heresi G, Tong MZ, Bartholomew JR.
Am J Cardiol. 2019 Nov 1;124(9):1465-1469. Epub 2019 Aug 7.
PMID: 31495443

Invasive hemodynamic assessment of patients with submassive pulmonary embolism.
Khandhar SJ, Mehta M, Cilia L, Palevsky H, Matthai W, Rivera-Lebron B, Toma C.Catheter Cardiovasc Interv. 2019 Sep 9. doi: 10.1002/ccd.28491. [Epub ahead of print]
PMID: 31498965