Welcome to Issue 21 of PERTinent Updates, featuring a select group of articles for your review. We aim to inform and update our members with the most recent major developments in the fields of PERT/VTE so that we in the PERT ConsortiumTM can continue to be at the leading edge of improving care for this vulnerable and overlooked group of patients.

Issue Highlight:
From Our Own

The PERT consortium is pleased to announce their first consensus practice document to help physicians caring for patients with acute PE. In this article, the PERT consortium provides a comprehensive review of the diagnosis, treatment, and follow-up of acute PE, including both clinical data and consensus opinion to provide guidance for clinicians caring for these patients.

• Diagnosis, Treatment and Follow Up of Acute Pulmonary Embolism: Consensus Practice from the PERT Consortium.

Epidemiology

Venous thromboembolism as a cause of severe maternal morbidity and mortality in the United States.
Abe K, Kuklina EV, Hooper WC, Callaghan WM.
Semin Perinatol. 2019 Jun;43(4):200-204.
doi: 10.1053/j.semperi.2019.03.004. Epub 2019 Mar 9. Review.
PMID: 30935751

Occult Chronic Thromboembolic Disease in Patients Presenting for Surgical Pulmonary Embolectomy.
DiChiacchio L, Pasrija C, Boulos FM, Ramani G, Jeudy J, Deatrick KB, Griffith BP, Kon ZN.
Ann Thorac Surg. 2019 May 2. pii: S0003-4975(19)30605-8.
doi: 10.1016/j.athoracsur.2019.03.088. [Epub ahead of print]
PMID: 31055039

Diagnostic Testing/Risk Stratification

Usefulness of standard computed tomography pulmonary angiography performed for acute pulmonary embolism for identification of chronic thromboembolic pulmonary hypertension: results of the InShape III study.
Ende-Verhaar YM, Meijboom LJ, Kroft LJM, Beenen LFM, Boon GJAM, Middeldorp S, Nossent EJ, Symersky P, Huisman MV, Bogaard HJ, Noordegraaf AV, Klok FA.
J Heart Lung Transplant. 2019 Mar 15. pii: S1053-2498(19)31424-X.
doi: 10.1016/j.healun.2019.03.003. [Epub ahead of print]
PMID: 30962147

Could the YEARS algorithm be used to exclude pulmonary embolism during pregnancy? Data from the CT-PE-pregnancy study.
Langlois E, Cusson-Dufour C, Moumneh T, Elias A, Meyer G, Lacut K, Schmidt J, Le Gall C, Chauleur C, Glauser F, Robert-Ebadi H, Righini M, Le Gal G.
J Thromb Haemost. 2019 May 20. 3
doi: 10.1111/jth.14483. [Epub ahead of print]
PMID: 31108013

Therapy Related

Extended Anticoagulation for VTE: A Systematic Review and Meta-Analysis.
Mai V, Guay CA, Perreault L, Bonnet S, Bertoletti L, Lacasse Y, Jardel S, Lega JC, Provencher S.
Chest. 2019 Jun;155(6):1199-1216.
doi: 10.1016/j.chest.2019.02.402.
PMID: 31174635

From Our Own…

A Prospective, Single-Arm, Multicenter Trial of Catheter-Directed Mechanical Thrombectomy for Intermediate-Risk Acute Pulmonary Embolism: The FLARE Study.
Tu T, Toma C, Tapson VF, Adams C, Jaber WA, Silver M, Khandhar S, Amin R, Weinberg M, Engelhardt T, Hunter M, Holmes D, Hoots G, Hamdalla H, Maholic RL, Lilly SM, Ouriel K, Rosenfield K; FLARE Investigators.
JACC Cardiovasc Interv. 2019 May 13;12(9):859-869.
doi: 10.1016/j.jcin.2018.12.022.
PMID: 31072507

Acute Treatment of Pulmonary Embolism: Part 2.
Rali P, Gandhi V, Sockrider M.
Am J Respir Crit Care Med. 2019 Apr 15;199(8):P15-P16.
doi: 10.1164/rccm.1998P15
PMID: 30985211

Diagnosis, Treatment and Follow Up of Acute Pulmonary Embolism: Consensus Practice from the PERT Consortium.
Rivera-Lebron B, McDaniel M, Ahrar K, Alrifai A, Dudzinski DM, Fanola C, Blais D, Janicke D, Melamed R, Mohrien K, Rozycki E, Ross CB, Klein AJ, Rali P, Teman NR, Yarboro L, Ichinose E, Sharma AM, Bartos JA, Elder M, Keeling B, Palevsky H, Naydenov S, Sen P, Amoroso N, Rodriguez-Lopez JM, Davis GA, Rosovsky R, Rosenfield K, Kabrhel C, Horowitz J, Giri JS, Tapson V, Channick R; PERT Consortium.
Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029619853037.
doi: 10.1177/1076029619853037.
PMID: 31185730

Outcomes of fibrinolytic therapy for patients with metastatic cancer and acute pulmonary embolism.
Ogunbayo GO, Pecha R, Misumida N, Goodwin E, Ayoub K, Hillerson D, Elbadawi A, Abdel-Latif A, Elayi CS, Messerli AW, Smyth SS.
Pulm Pharmacol Ther. 2019 Apr 5. pii: S1094-5539(19)30039-2.
doi: 10.1016/j.pupt.2019.04.001. [Epub ahead of print]
PMID: 30959093

This issue of PERTinent Updates is

Sponsored by:
The PERT Consortium

Supported by:
Actelion Pharmaceuticals US, Inc.
EKOS, a BTG International Company