HI-PEITHO: A Randomized Trial of Ultrasound-facilitated, Catheter-directed, Thrombolysis Versus Anticoagulation for Acute Intermediate-high Risk Pulmonary Embolism: The Higher-risk Pulmonary Embolism Thrombolysis Study
The National PERT Consortium™ is proud to be part of the HI-PEITHO clinical trial in collaboration with Boston Scientific Corporation and the University Medical Center of the Johannes Gutenberg University of Mainz, Germany. HI-PEITHO will compare the use of the EkoSonic™ Endovascular System (EKOS) in combination with anticoagulation to anticoagulation alone for the treatment of acute, intermediate-high-risk pulmonary embolism (PE). The trial will assess whether treatment with EKOS in combination with anticoagulation is associated with a significant reduction in adverse events compared to anticoagulation alone.
The study started in August 2021 and is expected to be completed December 2024. At least 406 patients will be randomized at 65 institutions across the United States and Europe.
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