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Issue 31

Welcome to issue 31 of PERTinent Updates, featuring a select group of articles for your review. We aim to inform and update our members with the most recent major developments in the fields of PE/VTE so that we in the PERT Consortium® can continue to be at the leading edge of improving care for this vulnerable and overlooked group of patients.

VTE and COVID-19

Pulmonary embolism in hospitalised patients with COVID-19.
Whyte MB, Kelly PA, Gonzalez E, Arya R, Roberts LN.
Thromb Res. 2020 Jul 10;195:95-99. doi: 10.1016/j.thromres.2020.07.025. [Epub ahead of print] PMID: 32682004

Association between Pulmonary Embolism and COVID-19 in ED patients Undergoing CTPA: the PEPCOV international retrospective study.
Freund Y, Drogrey M, Miró Ò, Marra A, Féral-Pierssens AL, Penaloza A, Lara Hernandez BA, Beaune S, Gorlicki J, Vattinada Ayar P, Truchot J, Pena B, Aguirre A, Fémy F, Javaud N, Chauvin A, Chouihed T, Montassier E, Claret PG, Occelli C, Roussel M, Brigant F, Ellouze S, Le Borgne P, Laribi S, Simon T, Lucidarme O, Cachanado M, Bloom B; IMPROVING EMERGENCY CARE FHU Collaborators.
Acad Emerg Med. 2020 Jul 30. doi: 10.1111/acem.14096. Online ahead of print.
PMID: 32734624

Venous Thromboembolism in COVID-19 ICU Patients
Moll M, Zon RL, Sylvester KW, Chen EC, Cheng V, Connell NT, Fredenburgh LE, Baron RM, Cho MH, Woolley AE, Connors JM.
CHEST (2020), doi: https://doi.org/10.1016/j.chest.2020.07.031.

PE Review

Pulmonary embolism: update on management and controversies.
Duffett L, Castellucci LA, Forgie MA.
BMJ. 2020 Aug 5;370:m2177. doi: 10.1136/bmj.m2177.PMID: 32759284Review.

PE Diagnosis

Delayed Diagnosis in Pulmonary Embolism: Frequency, Patient Characteristics, and Outcome.
Mansella G, Keil C, Nickel CH, Eken C, Wirth C, Tzankov A, Peterson CJ, Aujesky D, Bingisser R.
Respiration. 2020 Jul 21:1-9. doi: 10.1159/000508396. Online ahead of print. PMID: 32694258

PE Treatment – Thrombolytic Use

International Survey of Thrombolytic Use for Treatment of Cardiac Arrest Due to Massive Pulmonary Embolism.
Rech MA, Horng M, Holzhausen JM, Van Berkel MA, Sokol SS, Peppard S, Hammond DA.
Version 2. Crit Care Explor. 2020 Jun 9;2(6):e0132. doi: 10.1097/CCE.0000000000000132. eCollection 2020 Jun.
PMID: 32695997

PE Treatment – Catheter-Directed Reperfusion

Catheter-Directed Thrombolysis in Submassive Pulmonary Embolism and Acute Cor Pulmonale.
Stein PD, Matta F, Hughes MJ.
Am J Cardiol. 2020 Jun 30:S0002-9149(20)30625-1. doi: 10.1016/j.amjcard.2020.06.048. Online ahead of print.
PMID: 32718549

VTE Treatment – IVC Filter 

Association of Inferior Vena Cava Filter Placement With Rates of Pulmonary Embolism in Patients With Cancer and Acute Lower Extremity Deep Venous Thrombosis.
Balabhadra S, Kuban JD, Lee S, Yevich S, Metwalli Z, McCarthy CJ, Huang SY, Tam A, Gupta S, Sheth SA, Sheth RA.
JAMA Netw Open. 2020 Jul 1;3(7):e2011079. doi: 10.1001/jamanetworkopen.2020.11079.
PMID: 32701160

VTE – Research Priorities

Venous thromboembolism research priorities: A scientific statement from the American Heart Association and the International Society on Thrombosis and Haemostasis.
Cushman M, Barnes GD, Creager MA, Diaz JA, Henke PK, Machlus KR, Nieman MT, Wolberg AS; American Heart Association Council on Peripheral Vascular Disease; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Epidemiology and Prevention; and the International Society on Thrombosis and Haemostasis. Circulation. 2020 Aug 11;142(6):e85-e94. PMID: 32776842.

PERT Consortium – From Our Own

Applying rigorous eligibility criteria to studies evaluating prognostic utility of serum biomarkers in pulmonary embolism: A systematic review and meta-analysis. 
Nithianandan H, Reilly A, Tritschler T, Wells P. 
Thromb Res. July 2020.  doi.org/10.1016/j.thromres.2020.07.037

A fortune teller’s dream or clinician’s nightmare: Right ventricular assessment for risk prediction in pulmonary embolism
Piazza G. 
Thrombosis Research (2020), https://doi.org/10.1016/j.thromres.2020.07.032

Clinical conundrum: concomitant high-risk pulmonary embolism and acute ischemic stroke.  
Lio KU, Jiménez D, Moores L, Rali P. 
Emerg Radiol. 2020;27(4):433-439. doi:10.1007/s10140-020-01772-7

Timing of parenteral anticoagulation after thrombolysis for the treatment of pulmonary embolism.  
Schwab-Daugherty EM, Peng MR, Caraccio EE, Stevens SM, Woller SC. 
Thromb Res. 2020;195:58-61. doi:10.1016/j.thromres.2020.07.001

Impact of Pulmonary Embolism Response Team on Anticoagulation Prescribing Patterns in Patients With Acute Pulmonary Embolism.
Kuhrau S, Masic D, Mancl E, Brailovsky Y, Porcaro K, Morris S, Haines J, Charo K, Fareed J, Darki A.
J Pharm Pract. 2020 Jul 15:897190020940125. doi: 10.1177/0897190020940125. [Epub ahead of print]
PMID: 32666864 [PubMed – as supplied by publisher]

Derivation and validation of a clinical prediction rule for thrombolysis-associated major bleeding in patients with acute pulmonary embolism: the BACS score.
Luis Jara-Palomares, David Jiménez, Behnood Bikdeli, Alfonso Muriel, Parth Rali, Yugo Yamashita, Takeshi Morimoto, Takeshi Kimura, Raphael Le Mao, Antoni Riera-Mestre, Ana Maestre, Fares Moustafa, Manuel Monreal.   [published online ahead of print, 2020 Jul 23]. Eur Respir J. 2020;2002336.
doi:10.1183/13993003.02336-2020

Clinical Characteristics and Outcomes of Women Presenting with Venous Thromboembolism during Pregnancy and Postpartum Period: Findings from the RIETE Registry.
Elgendy IY, Fogerty A, Blanco-Molina Á, Rosa V, Schellong S, Skride A, Portillo J, Lopez-Miguel P, Monreal M, Weinberg I.
Thromb Haemost. 2020 Jul 27. doi: 10.1055/s-0040-1714211. Online ahead of print.
PMID: 32717760