Welcome to issue 18 of PERTinent Updates, featuring a select group of articles for your review. We aim to inform and update our members with the most recent major developments in the fields of PERT/VTE so that we in the PERT Consortium™ can continue to be at the leading edge of improving care for this vulnerable and overlooked group of patients.

Issue Highlight:
From Our Own

EXPRESS: A Multidisciplinary Pulmonary Embolism Response Team (PERT) – Experience from a national multicenter consortium.

Therapy Related

Inhaled nitric oxide to treat intermediate risk pulmonary embolism: A multicenter randomized controlled trial.
Kline JA, Puskarich MA, Jones AE, Mastouri RA, Hall CL, Perkins A, Gundert E, Lahm T. Nitric Oxide. 2019 Jan 8. pii: S1089-8603(18)30196-4. doi: 10.1016/j.niox.2019.01.006. [Epub ahead of print]
PMID: 30633959

Prognosis

Incomplete echocardiographic recovery at 6 months predicts long-term sequelae after intermediate-risk pulmonary embolism. A post-hoc analysis of the Pulmonary Embolism Thrombolysis (PEITHO) trial.
Barco S, Russo M, Vicaut E, Becattini C, Bertoletti L, Beyer-Westendorf J, Bouvaist H, Couturaud F, Danays T, Dellas C, Duerschmied D, Empen K, Ferrari E, Galiè N, Jiménez D, Klok FA, Kostrubiec M, Kozak M, Kupatt C, Lang IM, Lankeit M, Meneveau N, Palazzini M, Pruszczyk P, Rugolotto M, Salvi A, Sanchez O, Schellong S, Sobkowicz B, Meyer G, Konstantinides SV.
Clin Res Cardiol. 2018 Dec 18. doi: 10.1007/s00392-018-1405-1. [Epub ahead of print]
PMID: 30564950

Prevention

Apixaban to Prevent Venous Thromboembolism in Patients with Cancer.
Carrier M, Abou-Nassar K, Mallick R, Tagalakis V, Shivakumar S, Schattner A, Kuruvilla P, Hill D, Spadafora S, Marquis K, Trinkaus M, Tomiak A, Lee AYY, Gross PL, Lazo-Langner A, El-Maraghi R, Goss G, Le Gal G, Stewart D, Ramsay T, Rodger M, Witham D, Wells PS; AVERT Investigators.
N Engl J Med. 2018 Dec 4. doi: 10.1056/NEJMoa1814468. [Epub ahead of print]
PMID: 30511879

Reviews

Thrombolytic therapy for pulmonary embolism.
Hao Q, Dong BR, Yue J, Wu T, Liu GJ.
Cochrane Database Syst Rev. 2018 Dec 18;12:CD004437. doi: 10.1002/14651858.CD004437.pub5. Review.

Pulmonary embolism critical care update: prognosis, treatment, and research gaps.
Chodakowski JD, Courtney DM.
Curr Opin Crit Care. 2018 Dec;24(6):540-546. doi: 10.1097/MCC.0000000000000558.
PMID: 30325344

From Our Own…

EXPRESS: A Multidisciplinary Pulmonary Embolism Response Team (PERT) – Experience from a national multicenter consortium.

Schultz J, Giordano N, Zheng H, Parry BA, Barnes GD, Heresi GA, Jaber W, Wood T, Todoran T, Courtney DM, Naydenov S, Khandhar S, Green P, Kabrhel C.
Pulm Circ. 2019 Jan 11:2045894018824563. doi: 10.1177/2045894018824563. [Epub ahead of print] No abstract available.
PMID: 30632901 [PubMed – as supplied by publisher]