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ISSUE 34

Welcome to issue 34 of PERTinent Updates, featuring a select group of articles for your review. We aim to inform and update our members with the most recent major developments in the fields of PE/VTE so that we in the PERT Consortium® can continue to be at the leading edge of improving care for this vulnerable and overlooked group of patients.

Guidelines

American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer. 
Lyman GH, Carrier M, Ay C, Di Nisio M, Hicks LK, Khorana AA, Leavitt AD, Lee AYY, Macbeth F, Morgan RL, Noble S, Sexton EA, Stenehjem D, Wiercioch W, Kahale LA, Alonso-Coello P.
Blood Adv. 2021 Feb 23;5(4):927-974.
doi: 10.1182/bloodadvances.2020003442. PMID: 33570602

Epidemiology

Incidence of Venous Thromboembolism in a Racially Diverse Population of Oklahoma County, Oklahoma.
Wendelboe AM, Campbell J, Ding K, Bratzler DW, Beckman MG, Reyes NL, Raskob GE.
Thromb Haemost. 2021 Jan 10.
doi: 10.1055/s-0040-1722189. Online ahead of print.

Prevalence of Pulmonary Embolism Among Patients With COPD Hospitalized With Acutely Worsening Respiratory Symptoms.
Couturaud F, Bertoletti L, Pastre J, Roy PM, Le Mao R, Gagnadoux F, Paleiron N, Schmidt J, Sanchez O, De Magalhaes E, Kamara M, Hoffmann C, Bressollette L, Nonent M, Tromeur C, Salaun PY, Barillot S, Gatineau F, Mismetti P, Girard P, Lacut K, Lemarié CA, Meyer G, Leroyer C; PEP Investigators.
JAMA. 2021 Jan 5;325(1):59-68.
doi: 10.1001/jama.2020.23567.

Pulmonary embolism at autopsy in cancer patients.
Gimbel IA, Mulder FI, Bosch FTM, Freund JE, Guman N, van Es N, Kamphuisen PW, Büller HR, Middeldorp S.
J Thromb Haemost. 2021 Jan 27.
doi: 10.1111/jth.15250. Online ahead of print.

Treatment

Effectiveness and Safety of Apixaban, Low-Molecular-Weight Heparin, and Warfarin among Venous Thromboembolism Patients with Active Cancer: A U.S. Claims Data Analysis.
Cohen A, Keshishian A, Lee T, Wygant G, Rosenblatt L, Hlavacek P, Mardekian J, Wiederkehr D, Sah J, Luo X.
Thromb Haemost. 2020 Nov 10.
doi: 10.1055/s-0040-1718728. Online ahead of print

Review

Prognostic significance of computed tomography-assessed right ventricular enlargement in low-risk patients with pulmonary embolism: Systematic review and meta-analysis.
Andrade I, Mehdipoor G, Le Mao R, García-Sánchez A, Pintado B, Pérez A, Rodríguez C, Velasco D, Bikdeli B, Jiménez D.
Thromb Res. 2021 Jan;197:48-55.
doi: 10.1016/j.thromres.2020.10.034. Epub 2020 Nov 5.

Why, Whom, and How to Screen for Chronic Thromboembolic Pulmonary Hypertension after Acute Pulmonary Embolism. 
Boon GJAM, Huisman MV, Klok FA.
Semin Thromb Hemost. 2020 Dec 21.
doi: 10.1055/s-0040-1718925. Online ahead of print.

From Our Own

Sex-related Differences in D-dimer Levels for Venous Thromboembolism Screening.
Reagh JJ, Zheng H, Stolz U, Parry BA, Chang AM, House SL, Giordano NJ, Cohen J, Singer AJ, Francis S, Prochaska JH, Zeserson E, Wild PS, Limkakeng AT Jr, Walters EL, LoVecchio F, Theodoro D, Hollander JE, Kabrhel C, Fermann GJ.
Acad Emerg Med. 2021 Jan 26.
doi: 10.1111/acem.14220. Online ahead of print

Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19.
Al-Samkari H, Gupta S, Leaf RK, Wang W, Rosovsky RP, Brenner SK, Hayek SS, Berlin H, Kapoor R, Shaefi S, Melamed ML, Sutherland A, Radbel J, Green A, Garibaldi BT, Srivastava A, Leonberg-Yoo A, Shehata AM, Flythe JE, Rashidi A, Goyal N, Chan L, Mathews KS, Hedayati SS, Dy R, Toth-Manikowski SM, Zhang J, Mallappallil M, Redfern RE, Bansal AD, Short SAP, Vangel MG, Admon AJ, Semler MW, Bauer KA, Hernán MA, Leaf DE.
Ann Intern Med. 2021 Jan 26.
doi: 10.7326/M20-6739. Online ahead of print.

Sex differences in presentation, management, and outcomes among patients hospitalized with acute pulmonary embolism. 
Pribish AM, Beyer SE, Krawisz AK, Weinberg I, Carroll BJ, Secemsky EA.
Vasc Med. 2020 Nov 17:1358863X20964577. 
doi: 10.1177/1358863X20964577. Online ahead of print.

Incidence of venous thromboembolism in coronavirus disease 2019: An experience from a single large academic center. 
Rali P, O’Corragain O, Oresanya L, Yu D, Sheriff O, Weiss R, Myers C, Desai P, Ali N, Stack A, Bromberg M, Lubitz AL, Panaro J, Bashir R, Lakhter V, Caricchio R, Gupta R, Dass C, Maruti K, Lu X, Rao AK, Cohen G, Criner GJ, Choi ET;
Temple University COVID-19 Research Group. J Vasc Surg Venous Lymphat Disord. 2020 Oct 5:S2213-333X(20)30524-2. 
doi: 10.1016/j.jvsv.2020.09.006. Online ahead of print

Incidence of venous thromboembolism and bleeding among hospitalized patients with COVID-19: a systematic review and meta-analysis. 
Jiménez D, García-Sanchez A, Rali P, Muriel A, Bikdeli B, Ruiz-Artacho P, Le Mao R, Rodríguez C, Hunt BJ, Monreal M.Jiménez D, et al.
Chest. 2020 Nov 17:S0012-3692(20)35146-1. 
doi: 10.1016/j.chest.2020.11.005. Online ahead of print.