Welcome to issue 17 of PERTinent Updates, featuring a select group of articles for your review. We aim to inform and update our members with the most recent major developments in the fields of PERT/VTE so that we in the PERT Consortium™ can continue to be at the leading edge of improving care for this vulnerable and overlooked group of patients.

Issue Highlight:
Upcoming Trials

Residual pulmonary vascular obstruction and recurrence after acute pulmonary embolism: protocol for a systematic review and meta-analysis of individual participant data.

Therapy Related

The Incidence and Outcomes of Surgical Pulmonary Embolectomy in North America.
Kon ZN, Pasrija C, Bittle GJ, Vemulapalli S, Grau-Sepulveda MV, Matsouaka R, Deatrick KB, Taylor BS, Gammie JS, Griffith BP.
Ann Thorac Surg. 2018 Nov 23. pii: S0003-4975(18)31687-4. doi: 10.1016/j.athoracsur.2018.10.035. [Epub ahead of print]
PMID: 30476479

Systemic thrombolysis in haemodynamically unstable pulmonary embolism: The earlier the better?
Zuin M, Rigatelli G, Carraro M, Pastore G, Lanza D, Zonzin P, Zuliani G, Roncon L.
Thromb Res. 2018 Nov 29;173:117-123. doi: 10.1016/j.thromres.2018.11.029.
PMID: 30522023
PMID: 30528278

Risk Stratification

Meta-Analysis of Prevalence and Short-Term Prognosis of Hemodynamically Unstable Patients With Symptomatic Acute Pulmonary Embolism.
Quezada CA, Bikdeli B, Barrios D, Barbero E, Chiluiza D, Muriel A, Casazza F, Monreal M, Yusen RD, Jiménez D.
Am J Cardiol. 2018 Nov 26. pii: S0002-9149(18)32090-3. doi: 10.1016/j.amjcard.2018.11.009. [Epub ahead of print]
PMID: 30528278

Increasing Safe Outpatient Management of Emergency Department Patients With Pulmonary Embolism: A Controlled Pragmatic Trial.
Vinson DR, Mark DG, Chettipally UK, Huang J, Rauchwerger AS, Reed ME, Lin JS, Kene MV, Wang DH, Sax DR, Pleshakov TS, McLachlan ID, Yamin CK, Elms AR, Iskin HR, Vemula R, Yealy DM, Ballard DW; eSPEED Investigators of the KP CREST Network.
Ann Intern Med. 2018 Dec 18;169(12):855-865. doi: 10.7326/M18-1206. Epub 2018 Nov 13.
PMID: 30422263

Reviews

Venous Thromboembolism: Advances in Diagnosis and Treatment.
Tritschler T, Kraaijpoel N, Le Gal G, Wells PS.
JAMA. 2018 Oct 16;320(15):1583-1594. doi: 10.1001/jama.2018.14346. Review.
PMID: 30326130

Upcoming Trials

Residual pulmonary vascular obstruction and recurrence after acute pulmonary embolism: protocol for a systematic review and meta-analysis of individual participant data.
Robin P, Eddy M, Sikora L, Le Roux PY, Carrier M, Couturaud F, Planquette B, Pesavento R, Rodger M, Salaun PY, Le Gal G.
BMJ Open. 2018 Nov 28;8(11):e023939. doi: 10.1136/bmjopen-2018-023939.
PMID: 30498046

From Our Own…

Chronic thromboembolic pulmonary hypertension.
Kim NH, Delcroix M, Jais X, Madani MM, Matsubara H, Mayer E, Ogo T, Tapson VF, Ghofrani HA, Jenkins DP.
Eur Respir J. 2018 Dec 13. pii: 1801915. doi: 10.1183/13993003.01915-2018. [Epub ahead of print]
PMID: 30545969

Prevalence and Predictors of Deep Vein Thrombosis in Critically Ill Medical Patients Who Underwent Diagnostic Duplex Ultrasonography.
Gibson CD, Colvin MO, Park MJ, Lai Q, Lin J, Negassa A, Shah CD, Langston MD.
J Intensive Care Med. 2018 Nov 19:885066618813300. doi: 10.1177/0885066618813300.
PMID: 30453801

Pulmonary Embolism Response Teams: A Novel Approach for the Care of Complex Patients With Pulmonary Embolism.
Porres-Aguilar M, Anaya-Ayala JE, Heresi GA, Rivera-Lebron BN.
Clin Appl Thromb Hemost. 2018 Nov 19:1076029618812954. doi: 10.1177/1076029618812954. [Epub ahead of print]
PMID: 30453745

Pulmonary Embolism Response Team: Inpatient Structure, Outpatient Follow-up, and Is It the Current Standard of Care?
Rosovsky R, Borges J, Kabrhel C, Rosenfield K.
Clin Chest Med. 2018 Sep;39(3):621-630. doi: 10.1016/j.ccm.2018.04.019. Review.
PMID: 30122185

Usefulness of a Computerized Reminder System to Improve Inferior Vena Cava Filter Retrieval and Complications.
Mikhael B, Albaghdadi M, Abtahian F, MacKay C, Secemsky E, Jaff MR, Weinberg I.
Am J Cardiol. 2018 Oct 19. pii: S0002-9149(18)31969-6. doi: 10.1016/j.amjcard.2018.09.040. [Epub ahead of print]
PMID: 30424866

Venous Thromboembolism: A Survey of Oral Anticoagulant Preferences in the Treatment of Challenging Patient Populations.
Moyer GC, Bannow BS, Thornburg C, Rosovsky R, Wang TF, Woller S, Thornhill D, Kreuziger LB.
Clin Appl Thromb Hemost. 2018 Oct 2:1076029618804080. doi: 10.1177/1076029618804080. [Epub ahead of print]
PMID: 30278776