Welcome to the fourteenth monthly email of PERTinent Updates featuring a select group of articles for your review. We aim to inform and update our members with the most recent major developments in the fields of PERT/VTE so that we in the PERT Consortium can continue to be at the leading edge of improving care for this vulnerable and overlooked group of patients.

A special congratulations goes out to Dr. Elbadawi whose research on “The impact of a multi-specialty team for high-risk pulmonary embolism on resident and fellow education” was first presented as a poster at our 4th annual PERT Scientific Symposium. PERT is committed to encouraging and recognizing research from young faculty and trainees.

Other articles from this month’s
From Our Own include…

• A pulmonary embolism response team (PERT) approach; initial experience from the Cleveland Clinic
• Epidemiology, Pathophysiology, and Natural History of Pulmonary Embolism
• The Role of the Pulmonologist in a Pulmonary Embolism Response Team (PERT): A Time to Come on Stage
• Evaluation of the pulmonary embolism rule out criteria (PERC rule) in children evaluated for suspected pulmonary embolism
• Catheter-Directed Thrombolysis for Submassive Pulmonary Embolism

Risk Stratification

Age-adjusted versus clinical probability-adjusted D-dimer to exclude pulmonary embolism.
TakachLapner S, Stevens SM, Woller SC, Snow G, Kearon C.
Thromb Res. 2018 May 5;167:15-19. doi: 10.1016/j.thromres.2018.05.003. [Epub ahead of print]
PMID: 29753834

Early discharge of patients with pulmonary embolism in daily clinical practice: A prospective observational study comparing clinical gestalt and clinical rules.
Vanni S, Becattini C, Nazerian P, Bova C, Stefanone VT, Cimini LA, Viviani G, Caviglioli C, Sanna M, Pepe G, Grifoni S.
Thromb Res. 2018 May 8;167:37-43.doi: 10.1016/j.thromres.2018.05.008. [Epub ahead of print]
PMID: 29778034

Prophylaxis

Interventions for implementation of thromboprophylaxis in hospitalized patients at risk for venous thromboembolism.
Kahn SR, Morrison DR, Diendéré G, Piché A, Filion KB, Klil-Drori AJ, Douketis JD, Emed J, Roussin A, Tagalakis V, Morris M, Geerts W.
Cochrane Database Syst Rev. 2018 Apr 24;4:CD008201. doi: 10.1002/14651858.CD008201.pub3. Review.
PMID: 29687454

Reviews

Novel Anticoagulant Treatment for Pulmonary Embolism with Direct Oral Anticoagulants Phase 3 Trials and Clinical Practice.
Tromeur C, van der Pol LM, Mairuhu ATA, Leroyer C, Couturaud F, Huisman MV, Klok FA. Semin Intervent Radiol. 2018 Jun;35(2):83-91. doi: 10.1055/s-0038-1642622. Epub 2018 Jun 4. Review.
PMID: 29872242

Management

Management of Low-Risk Pulmonary Embolism Patients Without Hospitalization: The Low-Risk Pulmonary Embolism Prospective Management Study.
Bledsoe JR, Woller SC, Stevens SM, Aston V, Patten R, Allen T, Horne BD, Dong L, Lloyd J, Snow G, Madsen T, Elliott CG.
Chest. 2018 Aug;154(2):249-256.
doi: 10.1016/j.chest.2018.01.035. Epub 2018 Feb 2.
PMID: 29410163

From Our Own…

Chronic Thromboembolic Pulmonary Hypertension: Evolving Therapeutic Approaches for Operable and Inoperable Disease.
Mahmud E, Madani MM, Kim NH, Poch D, Ang L, Behnamfar O, Patel MP, Auger WR. J Am Coll Cardiol. 2018 May 29;71(21):2468-2486. doi: 10.1016/j.jacc.2018.04.009. Review.
PMID: 29793636

The impact of a multi-specialty team for high risk pulmonary embolism on resident and fellow education.
Elbadawi A, Wright C, Patel D, Chen YL, Mazzillo J, Cameron P, Barnes GD, Cameron SJ.  Vasc Med. 2018 May 1:1358863X18767753. doi: 10.1177/1358863X18767753. [Epub ahead of print]
PMID: 29786477

Evaluation of the pulmonary embolism rule out criteria (PERC rule) in children evaluated for suspected pulmonary embolism.
Kline JA, Ellison AM, Kanis J, Pike JW, Hall CL.
Thromb Res. 2018 May 24;168:1-4. doi: 10.1016/j.thromres.2018.05.026. [Epub ahead of print]
PMID: 29864629

A pulmonary embolism response team (PERT) approach: initial experience from the Cleveland Clinic.
Mahar JH, Haddadin I, Sadana D, Gadre A, Evans N, Hornacek D, Mahlay NF, Gomes M, Joseph D, Serhal M, Tong MZ, Bauer SR, Militello M, Silver B, Shishehbor M, Bartholomew JR, Heresi GA.
J Thromb Thrombolysis. 2018 May 31.doi: 10.1007/s11239-018-1686-2. [Epub ahead of print]
PMID: 29855780

The Role of the Pulmonologist in a Pulmonary Embolism Response Team (PERT): A Time to Come on Stage.
Rodríguez Chiaradía DA, Cuttica MJ, Jimenez D.
Arch Bronconeumol. 2018 May 19.pii: S0300-2896(18)30144-3. doi: 10.1016/j.arbres.2018.04.002. [Epub ahead of print] English, Spanish. No abstract available.
PMID: 29789172

Catheter-Directed Thrombolysis for Submassive Pulmonary Embolism.
Chiarello MA, Sista AK. Semin Intervent Radiol. 2018 Jun;35(2):122-128. doi: 10.1055/s-0038-1642041. Epub 2018 Jun 4. Review.
PMID: 2987224

Epidemiology, Pathophysiology, and Natural History of Pulmonary Embolism.
Turetz M, Sideris AT, Friedman OA,Triphathi N, Horowitz JM.
Semin Intervent Radiol. 2018 Jun;35(2):92-98. doi: 10.1055/s-0038-1642036. Epub 2018 Jun 4. Review.
PMID: 29872243