Welcome to issue 15 of PERTinent Updates, featuring a select group of articles for your review. We aim to inform and update our members with the most recent major developments in the fields of PERT/VTE so that we in the PERT Consortium can continue to be at the leading edge of improving care for this vulnerable and overlooked group of patients.

In addition, we are gearing for a new webinar series beginning on October 10th at 6 PM that you won’t want to miss. We will be sending out a second wave of invitations towards the end of this week so keep an eye on your inbox.

Other articles from this month’s
From Our Own include…

• Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension

• A Randomized Trial of the Optimum Duration of Acoustic Pulse Thrombolysis Procedure in Acute Intermediate-Risk Pulmonary Embolism: The OPTALYSE PE Trial

• The OPTALYSE PE Trial: Another Step Toward Understanding the Truth About Catheter-Directed Thrombolysis for Submassive Pulmonary Embolism

• Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement.

• Extracorporeal membrane oxygenation in acute massive pulmonary embolism: a case series and review of the literature.

• A Five-year and Single-centre Experience on Ultrasound Assisted, Catheter-Directed Thrombolysis in Patients with Pulmonary Embolism at High-Risk and Intermediate-High-Risk.

 

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Epidemiology

Epidemiology, patterns of care and mortality for patients with hemodynamically unstable acute symptomatic pulmonary embolism
Jiménez D, Bikdeli B, Barrios D, Quezada A, Del Toro J, Vidal G, Mahé I, Quere I, Loring M, Yusen RD, Monreal M; RIETE investigators.
Int J Cardiol. 2018 Jul 16. pii: S0167-5273(18)30785-X.
doi: 10.1016/j.ijcard.2018.07.059. [Epub ahead of print]
PMID: 30025658

 

Predictive value of venous thromboembolism (VTE)-BLEED to predict major bleeding and other adverse events in a practice-based cohort of patients with VTE: results of the XALIA study.
Klok FA, Barco S, Turpie AGG, Haas S, Kreutz R, Mantovani LG, Gebel M, Herpers M, Bugge JP, Kostantinides SV, Ageno W.
Br J Haematol. 2018 Aug 19.
doi: 10.1111/bjh.15533. [Epub ahead of print]
PMID: 30123981

 

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Therapy

Reduced-dose direct oral anticoagulants in the extended treatment of venous thromboembolism: a systematic review and meta-analysis.
Vasanthamohan L, Boonyawat K, Chai-Adisaksopha C, Crowther M.
J Thromb Haemost. 2018 Jul;16(7):1288-1295.
doi: 10.1111/jth.14156. Epub 2018 Jun 17.
PMID: 29772108

 

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Economics

Healthcare Cost Impact of Continued Anticoagulation with Rivaroxaban versus Aspirin for Prevention of Recurrent Symptomatic Venous Thromboembolism in the EINSTEIN-CHOICE Trial Population.
Wells PS, Prins MH, Beyer-Westendorf J, Lensing AW, Haskell L, Levitan B, Laliberté F, Ashton V, Xiao Y, Lejeune D, Crivera C, Lefebvre P, Zhao Q, Yuan Z, Schein J, Prandoni P.
Chest. 2018 Sep 7. pii: S0012-3692(18)32412-7. doi: 10.1016/j.chest.2018.08.1059. [Epub ahead of print]

 

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Review

Contemporary Management of the High-Risk Pulmonary Embolism: The Clot Thickens.
Reardon PM, Yadav K, Hendin A, Karovitch A, Hickey M.
J Intensive Care Med. 2018 Aug 1:885066618789879.
doi: 10.1177/0885066618789879. [Epub ahead of print]
PMID: 30068253

 

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From Our Own…

Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension. Moriarty JM, Khan SN, Kao SD, Saggar R. Cardiovascular and interventional radiology. 2018 Jul 23:1-4. doi.org/10.1007/s00270-018-2012-2

A Randomized Trial of the Optimum Duration of Acoustic Pulse Thrombolysis Procedure in Acute Intermediate-Risk Pulmonary Embolism: The OPTALYSE PE Trial Tapson VF, Sterling K, Jones N, Elder M, Tripathy U, Brower J, Maholic RL, Ross CB, Natarajan K, Fong P, Greenspon L, Tamaddon H, Piracha AR, Engelhardt T, Katopodis J, Marques V, Sharp ASP, Piazza G, Goldhaber SZ. JACC Cardiovasc Interv. 2018 Jul 23;11(14):1401-1410. doi: 10.1016/j.jcin.2018.04.008 PMID: 30025734

The OPTALYSE PE Trial: Another Step Toward Understanding the Truth About Catheter-Directed Thrombolysis for Submassive Pulmonary Embolism. Sista AK. JACC Cardiovasc Interv. 2018 Jul 23;11(14):1411-1413. doi: 10.1016/j.jcin.2018.05.014. No abstract available. PMID: 30025735

Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement. Lahm T, Douglas IS, Archer SL, Bogaard HJ, Chesler NC, Haddad F, Hemnes AR, Kawut SM, Kline JA, Kolb TM, Mathai SC, Mercier O, Michelakis ED, Naeije R, Tuder RM, Ventetuolo CE, Vieillard-Baron A, Voelkel NF, Vonk-Noordegraaf A, Hassoun PM; American Thoracic Society Assembly on Pulmonary Circulation. Am J Respir Crit Care Med. 2018 Aug 15;198(4):e15-e43. doi: 10.1164/rccm.201806-1160ST. PMID: 30109950

Extracorporeal membrane oxygenation in acute massive pulmonary embolism: a case series and review of the literature. Al-Bawardy R, Rosenfield K, Borges J, Young MN, Albaghdadi M, Rosovsky R, Kabrhel C. Perfusion. 2018 Jul 1:267659118786830. doi: 10.1177/0267659118786830. [Epub ahead of print] PMID: 30009670

A Five-year and Single-centre Experience on Ultrasound Assisted, Catheter Directed Thrombolysis in Patients with Pulmonary Embolism at High-Risk and Intermediate-High-Risk. Kaymaz C, Akbal OY, Hakgor A, Tokgoz HC, Karagoz A, Tanboga IH, Tanyeri S, Keskin B, Turkday S, Demir D, Dogan C, Bayram Z, Acar RD, Guvendi B, Ozdemir N, Tapson VF, Konstantinides S. Euro Intervention. 2018 Aug 7. pii: EIJ-D-18-00371. doi: 10.4244/EIJ-D-18-00371. [Epub ahead of print] PMID: 30082262 [PubMed – as supplied by publisher]