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Issue 40

The recent edition of PERTinent updates brought to you by The PERT Consortium® Education Committee.

Epidemiology

Association Between Black Race, Clinical Severity, and Management of Acute Pulmonary Embolism: A Retrospective Cohort Study.

Phillips AR, Reitz KM, Myers S, Thoma F, Andraska EA, Jano A, Sridharan N, Smith RE, Mulukutla SR, Chaer R.
J Am Heart Assoc. 2021 Aug 25:e021818.
doi: 10.1161/JAHA.121.021818. Online ahead of print.
PMID: 34431356

Prevention

Abelacimab for Prevention of Venous Thromboembolism.

Verhamme P, Yi BA, Segers A, Salter J, Bloomfield D, Büller HR, Raskob GE, Weitz JI; ANT-005 TKA Investigators.
N Engl J Med. 2021 Aug 12;385(7):609-617.
doi: 10.1056/NEJMoa2105872. Epub 2021 Jul 19.
PMID: 34297496

Treatment

Long-Term Risk for Major Bleeding During Extended Oral Anticoagulant Therapy for First Unprovoked Venous Thromboembolism : A Systematic Review and Meta-analysis. 

Khan F, Tritschler T, Kimpton M, Wells PS, Kearon C, Weitz JI, Büller HR, Raskob GE, Ageno W, Couturaud F, Prandoni P, Palareti G, Legnani C, Kyrle PA, Eichinger S, Eischer L, Becattini C, Agnelli G, Vedovati MC, Geersing GJ, Takada T, Cosmi B, Aujesky D, Marconi L, Palla A, Siragusa S, Bradbury CA, Parpia S, Mallick R, Lensing AWA, Gebel M, Grosso MA, Thavorn K, Hutton B, Le Gal G, Fergusson DA, Rodger MA; MAJESTIC Collaborators*.
Ann Intern Med. 2021 Sep 14.
doi: 10.7326/M21-1094. Online ahead of print.
PMID: 34516270

Catheter directed compared to systemically delivered thrombolysis for pulmonary embolism: a systematic review and meta-analysis.

Pasha AK, Siddiqui MU, Siddiqui MD, Ahmed A, Abdullah A, Riaz I, Murad MH, Bjarnason H, Wysokinski WE, McBane RD 2nd.
J Thromb Thrombolysis. 2021 Aug 31.
doi: 10.1007/s11239-021-02556-7. Online ahead of print.
PMID: 34463919

Case Reports

A patient with pulmonary embolism takes a surprising HIT: a case report.

Wasserstrum Y, Lubetzky A, Goitein O, Matetzky S.
Eur Heart J Case Rep. 2021 Aug 18;5(8):ytab304.
doi: 10.1093/ehjcr/ytab304. eCollection 2021 Aug.
PMID: 34476337

From Our Own

Heart rate and mortality in patients with acute symptomatic pulmonary embolism.

Jaureguízar A, Jiménez D, Bikdeli B, Ruiz-Artacho P, Muriel A, Tapson V, López-Reyes R, Valero B, Kenet G, Monreal M; RIETE investigators.
Chest. 2021 Aug 31:S0012-3692(21)03831-9.
doi: 10.1016/j.chest.2021.08.059. Online ahead of print.
PMID: 34478718

Nuts and bolts of COVID-19 associated coagulopathy: the essentials for management and treatment [published online ahead of print, 2021 Sep 11].

Lindsay PJ, Rosovsky R, Bittner EA, Chang MG.
Postgrad Med. 2021;1-13.
doi:10.1080/00325481.2021.1974212

Chronic thromboembolic pulmonary hypertension anno 2021.

Nossent EJ, Meijboom LJ, Bogaard HJ, Klok FA.
Curr Opin Cardiol. 2021 Aug 23.
doi: 10.1097/HCO.0000000000000907. Online ahead of print.
PMID: 34433194

Triaging acute pulmonary embolism for home treatment by Hestia or simplified PESI criteria: the HOME-PE randomized trial.

Roy PM, Penaloza A, Hugli O, Klok FA, Arnoux A, Elias A, Couturaud F, Joly LM, Lopez R, Faber LM, Daoud-Elias M, Planquette B, Bokobza J, Viglino D, Schmidt J, Juchet H, Mahe I, Mulder F, Bartiaux M, Cren R, Moumneh T, Quere I, Falvo N, Montaclair K, Douillet D, Steinier C, Hendriks SV, Benhamou Y, Szwebel TA, Pernod G, Dublanchet N, Lapebie FX, Javaud N, Ghuysen A, Sebbane M, Chatellier G, Meyer G, Jimenez D, Huisman MV, Sanchez O; HOME-PE Study Group.
Eur Heart J. 2021 Aug 31;42(33):3146-3157.
doi: 10.1093/eurheartj/ehab373.
PMID: 34363386

Advanced management of intermediate-high risk pulmonary embolism.

Weinstein T, Deshwal H, Brosnahan SB.
Crit Care. 2021 Aug 31;25(1):311.
doi: 10.1186/s13054-021-03679-2.
PMID: 34461959 Review