PERTinent Updates
Issue 28

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Issue 28

Welcome to issue 28 of PERTinent Updates, featuring a select group of articles for your review. We aim to inform and update our members with the most recent major developments in the fields of PERT/VTE so that we in the PERT Consortium® can continue to be at the leading edge of improving care for this vulnerable and overlooked group of patients.
   
   

COVID-19 and Thrombosis Organization Resources Links

 
Internal Society of Thrombosis and Hematology – Journal of Thrombosis and Haemostasis COVID-19 Resources (12 Journal Articles)
Anticoagulation Forum COVID-19 Resources
American Society of Hematology – COVID19 FAQs and additional resource links
Thrombosis UK Practical guidance for prevention of thrombosis & management of coagulopathy & disseminated intravascular coagulation of patients infected w/COVID-19
Thrombosis Canada COVID-19 Clinical Resource Links
 

COVID-19 and Thrombosis Guidance Statements

 
American College of Cardiology COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up.
Journal of the American College of Cardiology (April 2020), doi: https://doi.org/10.1016/j.jacc.2020.04.031
 
Prevention and Treatment of Venous Thromboembolism Associated with Coronavirus Disease 2019 Infection: A Consensus Statement before Guidelines.
Zhai Z, Li C, Chen Y, Gerotziafas G, Zhang Z, Wan J, Liu P, Elalamy I, Wang C; Prevention Treatment of VTE Associated with COVID-19 Infection Consensus Statement Group, Pulmonary Embolism Pulmonary Vascular Diseases Group of the Chinese Thoracic Society, Pulmonary Embolism Pulmonary Vascular Disease Working Committee of Chinese Association of Chest Physicians, National Cooperation Group on Prevention Treatment of Pulmonary Embolism Pulmonary Vascular Disease, National Program Office for Prevention Treatment of Pulmonary Embolism Deep Vein Thrombosis, China Grade Center, Evidence-based Medicine Center of School of Basic Medical Sciences of Lanzhou University. Thromb Haemost. 2020 Apr 21. doi: 10.1055/s-0040-1710019.
[Epub ahead of print] PMID: 32316065
 
Practical diagnosis and treatment of suspected venous thromboembolism during COVID-19 Pandemic.
Obi AT, Barnes GD, Wakefield TW, Brown Rvt S, Eliason JL, Arndt E, Henke PK. J Vasc Surg Venous Lymphat Disord. 2020 Apr 16. pii: S2213-333X(20)30221-3. doi: 10.1016/j.jvsv.2020.04.009.
[Epub ahead of print] PMID: 32305585
 

VTE Risk and Epidemiology in COVID-19 Patients

 
Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia.
Cui S, Chen S, Li X, Liu S, Wang F. J Thromb Haemost. 2020 Apr 9. doi: 10.1111/jth.14830.
[Epub ahead of print] PMID: 32271988
 
Attention should be paid to venous thromboembolism prophylaxis in the management of COVID-19.
Wang T, Chen R, Liu C, Liang W, Guan W, Tang R, Tang C, Zhang N, Zhong N, Li S. Lancet Haematol. 2020 Apr 9. pii: S2352-3026(20)30109-5. doi: 10.1016/S2352-3026(20)30109-5. [Epub ahead of print] No abstract available.
PMID: 32278361
 
Incidence of thrombotic complications in critically ill ICU patients with COVID-19.
Klok FA, Kruip MJHA, van der Meer NJM, Arbous MS, Gommers DAMPJ, Kant KM, Kaptein FHJ, van Paassen J, Stals MAM, Huisman MV, Endeman H.
Thromb Res. 2020 Apr 10. pii: S0049-3848(20)30120-1. doi: 10.1016/j.thromres.2020.04.013.
[Epub ahead of print] PMID: 32291094
 
Pulmonary thrombosis in 2019-nCoV pneumonia?
Marongiu F, Grandone E, Barcellona D. J Thromb Haemost. 2020 Apr 15. doi: 10.1111/jth.14818. [Epub ahead of print] No abstract available.
PMID: 32293083
 
High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients.
Llitjos JF, Leclerc M, Chochois C, Monsallier JM, Ramakers M, Auvray M, Merouani K. J Thromb Haemost. 2020 Apr 22. doi: 10.1111/jth.14869.
[Epub ahead of print] PMID: 32320517
 
Pulmonary Embolism in COVID-19 Patients: Awareness of an Increased Prevalence.
Poissy J, Goutay J, Caplan M, Parmentier E, Duburcq T, Lassalle F, Jeanpierre E, Rauch A, Labreuche J, Susen S; Lille ICU Haemostasis COVID-19 group. Circulation. 2020 Apr 24. doi: 10.1161/CIRCULATIONAHA.120.047430.
[Epub ahead of print] No abstract available. PMID: 32330083
 

Coagulopathy and COVID-19 Patients

 
Hematological findings and complications of COVID-19.
Terpos E, Ntanasis-Stathopoulos I, Elalamy I, Kastritis E, Sergentanis TN, Politou M, Psaltopoulou T, Gerotziafas G, Dimopoulos MA. Am J Hematol. 2020 Apr 13. doi: 10.1002/ajh.25829. [Epub ahead of print] Review.
PMID: 32282949
 
The Science Underlying COVID-19: Implications for the Cardiovascular System.
Liu PP, Blet A, Smyth D, Li H. Circulation. 2020 Apr 15. doi: 10.1161/CIRCULATIONAHA.120.047549.
[Epub ahead of print] PMID: 32293910
 
D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19.
Zhang L, Yan X, Fan Q, Liu H, Liu X, Liu Z, Zhang Z. J Thromb Haemost. 2020 Apr 19. doi: 10.1111/jth.14859.
[Epub ahead of print] PMID: 32306492
 

From Our Own Articles

 
Outcomes of catheter-directed thrombolysis vs. standard medical therapy in patients with acute submassive pulmonary embolism.
D’Auria S, Sezer A, Thoma F, Sharbaugh M, McKibben J, Maholic R, Avgerinos ED, Rivera-Lebron BN, Toma C. Pulm Circ. 2020 Apr 8;10(1):2045894019898368. doi: 10.1177/2045894019898368. eCollection 2020 Jan-Mar.
PMID: 32292583
 
First year experience of a pulmonary embolism response team with comparisons of outcomes between catheter directed therapy versus standard anticoagulation.
Khaing P, Paruchuri A, Eisenbrey JR, Merli GJ, Gonsalves CF, West FM, Awsare BK. Hosp Pract (1995). 2020 Feb;48(1):23-28. doi: 10.1080/21548331.2020.1706315. Epub 2020 Jan 3.
PMID: 31847615
 
Modern treatment trends and outcomes of pulmonary embolism with and without hemodynamic significance.
Mullan CW, Newman J, Geib M, Pichert MD, Saffarzadeh A, Hartman A, Lima B. Ann Thorac Surg. 2020 Mar 26. pii: S0003-4975(20)30415-X. doi: 10.1016/j.athoracsur.2020.02.041.
[Epub ahead of print] PMID: 32224241
 
Measuring functional limitations after venous thromboembolism: Optimization of the Post-VTE Functional Status (PVFS) Scale.
Boon GJAM, Barco S, Bertoletti L, Ghanima W, Huisman MV, Kahn SR, Noble S, Prandoni P, Rosovsky RP, Sista AK, Siegerink B, Klok FA. Thromb Res. 2020 Mar 30;190:45-51. doi: 10.1016/j.thromres.2020.03.020.
[Epub ahead of print] PMID: 32298840
 
New Paradigms of Extended Thromboprophylaxis in Medically Ill Patients.
MacDougall K, Spyropoulos AC. J Clin Med. 2020 Apr 2;9(4). pii: E1002. doi: 10.3390/jcm9041002. Review.
PMID: 32252423
 
Interventional Therapies in Acute Pulmonary Embolism.
Zhang R, Kobayashi T, Pugliese S, Khandhar S, Giri J. Interv Cardiol Clin. 2020 Apr;9(2):229-241. doi: 10.1016/j.iccl.2019.12.003. Epub 2020 Feb 10. Review.
PMID: 32147123
 
Percutaneous Thrombectomy in Emergency Department Patients with Pulmonary Embolism: The FLARE ED Sub-study.
Jaber WA, Kabrhel C, Rosenfield K, Tu T, Ouriel K, Tapson VF. J Emerg Med. 2020 Mar 24. pii: S0736-4679(19)31136-9. doi: 10.1016/j.jemermed.2019.11.044.
[Epub ahead of print] PMID: 32220546
 
 

PERT Consortium News

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PERT Consortium® Quality Database

Webinar

October 09, 2020

Townhall Webinar: Data Gaps in Acute PE and VTE in 2020: Filling in the Blanks