Welcome to the eleventh monthly email of PERTinent Updates featuring a select group of articles for your review. We aim to inform and update our members with the most recent major developments in the fields of PERT/VTE so that we in the PERT Consortium can continue to be at the leading edge of improving care for this vulnerable and overlooked group of patients.

This month’s “From Our Own” section features articles by Belinda Rivera-Lebron and Roy E. Smith in Clinical and Applied Thrombosis-Hemostasis; David Dudzinski, Nicholas Giordano, Christopher Kabrhel, Brian Ghoshhajra, Michael Jaff and Ido Weinberg in Journal of the American Heart Association; and Jeffrey Kline in the Academic Emergency Medicine.

Statistical analysis plan for the Pneumatic CompREssion for PreVENting Venous Thromboembolism (PREVENT) trial: a study protocol for a randomized controlled trial, is featured in “Upcoming Studies”. The Pneumatic CompREssion for Preventing VENous Thromboembolism (PREVENT) trial evaluates the effect of adjunctive intermittent pneumatic compression (IPC) with pharmacologic thromboprophylaxis compared to pharmacologic thromboprophylaxis alone on venous thromboembolism (VTE) in critically ill adults.

Diagnosis/Risk Assessment

Assessment of coexisting deep vein thrombosis for risk stratification of acute pulmonary embolism.
Quezada CA, Bikdeli B, Barrios D, Morillo R, Nieto R, Chiluiza D, Barbero E, Guerassimova I, García A, Yusen RD, Jiménez D; PROTECT investigators; Investigators of the PROTECT study. Thromb Res. 2018 Feb 17;164:40-44. doi: 10.1016/j.thromres.2018.02.140. [Epub ahead of print] PMID: 29476988

Effect of the Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department Patients: The PROPER Randomized Clinical Trial.
Freund Y, Cachanado M, Aubry A, Orsini C, Raynal PA, Féral-Pierssens AL, Charpentier S, Dumas F, Baarir N, Truchot J, Desmettre T, Tazarourte K, Beaune S, Leleu A, Khellaf M, Wargon M, Bloom B, Rousseau A, Simon T, Riou B; PROPER Investigator Group. JAMA. 2018 Feb 13;319(6):559-566. doi: 10.1001/jama.2017.21904. PMID: 29450523

Prophylaxis

Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty.
Anderson DR, Dunbar M, Murnaghan J, Kahn SR, Gross P, Forsythe M, Pelet S, Fisher W, Belzile E, Dolan S, Crowther M, Bohm E, MacDonald SJ, Gofton W, Kim P, Zukor D, Pleasance S, Andreou P, Doucette S, Theriault C, Abianui A, Carrier M, Kovacs MJ, Rodger MA, Coyle D, Wells PS, Vendittoli PA. N Engl J Med. 2018 Feb 22;378(8):699-707. doi: 10.1056/NEJMoa1712746. PMID: 29466159

Treatment

Mechanical circulatory support for acute right ventricular failure in the setting of pulmonary embolism.
Elder M, Blank N, Kaki A, Alraies MC, Grines CL, Kajy M, Hasan R, Mohamad T, Schreiber T. J Interv Cardiol. 2018 Mar 7. doi: 10.1111/joic.12503. [Epub ahead of print] PMID: 29514403

Review

Inferior Vena Cava Filters: Current and Future Concepts.
Kaufman JA. Interv Cardiol Clin. 2018 Jan;7(1):129-135. PMID: 29157519 

From Our Own…

Apixaban or Rivaroxaban Versus Warfarin for Treatment of Submassive Pulmonary Embolism After Catheter-Directed Thrombolysis.
Groetzinger LM, Miller TJ, Rivosecchi RM, Smith RE, Gladwin MT, Rivera-Lebron BN. Clin Appl Thromb Hemost. 2018 Jan 1:1076029618755311. doi: 10.1177/1076029618755311. [Epub ahead of print] PMID: 29455567

Cardiopulmonary Exercise Testing in Patients Following Massive and Submassive Pulmonary Embolism.
Albaghdadi MS, Dudzinski DM, Giordano N, Kabrhel C, Ghoshhajra B, Jaff MR, Weinberg I, Baggish A. J Am Heart Assoc. 2018 Mar 3;7(5). pii: e006841. doi: 10.1161/JAHA.117.006841. PMID: 29502109

Systematic review and meta-analysis of outcomes of patients with subsegmental pulmonary embolism with and without anticoagulation treatment.
Bariteau A, Stewart LK, Emmett TW, Kline JA. Acad Emerg Med. 2018 Mar 2. doi: 10.1111/acem.13399. [Epub ahead of print] PMID: 29498138