PERTinent Updates:
Issue 37



The recent edition of PERTinent updates brought to you by The PERT Consortium® Education Committee.




Efficacy and Safety of Direct Oral Anticoagulants in Venous Thromboembolism Compared to Traditional Anticoagulants in Morbidly Obese Patients: A Systematic Review and Meta-Analysis.

Katel A, Aryal M, Neupane A, Gosain R, Pathak R, Bhandari Y, Kouides P.  Cureus. 2021 Apr 20;13(4):e14572.
doi: 10.7759/cureus.14572.
PMID: 34026385; PMCID: PMC8135070.


Sex‐specific differences in clot resolution 3 weeks after acute pulmonary embolism managed with anticoagulants—A substudy of the EINSTEIN‐PE study

Hanke M. G. Wiegers, Josien van Es, Ákos F. Pap, Anthonie W. A. Lensing, Saskia Middeldorp, Luuk J. J. Scheres
Version of Record online:12 May 2021 


Safety and efficacy of catheter-directed therapy versus anticoagulation alone in a higher-risk acute pulmonary embolism population. 

Putnam A, Carey K, Marginean A, Serritella A, Friant J, Blair J, Shah A, Nathan S, Churpek M, Paul J.
J Thromb Thrombolysis. 2021 May 25.
doi: 10.1007/s11239-021-02481-9.
Online ahead of print.  PMID: 34036485


Therapy – Future Directions Antithrombotics and new interventions for venous thromboembolism: Exploring possibilities beyond factor IIa and factor Xa inhibition.

Mavromanoli AC, Barco S, Konstantinides SV. 
Res Pract Thromb Haemost. 2021 May 18;5(4).
doi: 10.1002/rth2.12509.
PMID: 34027284; PMCID: PMC8130658.


Tissue Plasminogen Activator in Critically Ill Adults with COVID-19

David J Douin, Shahzad Shaefi, Samantha K Brenner, Shruti Gupta, Isabel Park, Franklin L Wright, Kusum S Mathews, Lili Chan, Hanny Al-Samkari, Sarah Orfanos, Jared Radbel, and David E. Leaf PubMed: 33872546


Veno-Arterial Extracorporeal Membrane Oxygenation for Pulmonary Embolism after Systemic Thrombolysis. 

Prasad NK, Boyajian G, Tran D, Shah A, Jones KM, Madathil RJ, Deatrick KB, Cires-Drouet R, Kaczorowski DJ.
Semin Thorac Cardiovasc Surg. 2021 May 8:S1043-0679(21)00198-2.
doi: 10.1053/j.semtcvs.2021.04.004.
Online ahead of print. PMID: 33974966



From Our Own 

High incidence of patients lost to follow-up after venous thromboembolism diagnosis – Identifying an unmet need for targeted transition of care. 

Rokosh RS, Grazi JH, Ruohoniemi D, Yuriditsky E, Horowitz J, Sista AK, Jacobowitz GR, Rockman C, Maldonado TS.
Vascular. 2021 Jun 3:17085381211020969.
doi: 10.1177/17085381211020969.
Online ahead of print.  PMID: 34080914


PERTinent new insights into venous thromboembolism risk and management in hospitalized patients with COVID-19. 

Han H, Barnes GD.      
Vasc Med. 2021 May 20:1358863X211012776.
doi: 10.1177/1358863X211012776.
Online ahead of print. PMID: 34014133 No abstract available.


Pulmonary Embolism Response Team utilization during the COVID-19 pandemic.

Finn MT, Gogia S, Ingrassia JJ, Cohen M, Madhavan MV, Nabavi Nouri S, Brailovsky Y, Masoumi A, Fried JA, Uriel N, Agerstrand CI, Eisenberger A, Einstein AJ, Brodie D, B Rosenzweig E, Leon MB, Takeda K, Pucillo A, Green P, Kirtane AJ, Parikh SA, Sethi SS.
Vasc Med. 2021 Apr 4:1358863X21995896.
doi: 10.1177/1358863X21995896.
Epub ahead of print. PMID: 33818200; PMCID: PMC8047511.


Radiologic mimics of pulmonary embolism.

Matusov Y, Tapson VF.
Postgrad Med. 2021 May 18.
doi: 10.1080/00325481.2021.1931370.
Online ahead of print. PMID: 34000963 


Systematic review and meta-analysis of outcomes in patients with suspected pulmonary embolism. 

Patel P, Patel P, Bhatt M, Braun C, Begum H, Nieuwlaat R, Khatib R, Martins CC, Zhang Y, Etxeandia-Ikobaltzeta I, Varghese J, Alturkmani H, Bahaj W, Baig M, Kehar R, Mustafa A, Ponnapureddy R, Sethi A, Thomas M, Wooldridge D, Lim W, Bates SM, Lang E, Le Gal G, Haramati LB, Kline J, Righini M, Wiercioch W, Schünemann H, Mustafa RA. Blood Adv. 2021 Apr 27;5(8):2237-2244.
doi: 10.1182/bloodadvances.2020002398.
PMID: 33900385


Venoarterial Extracorporeal Membrane Oxygenation in Massive Pulmonary Embolism-Related Cardiac Arrest: A Systematic Review

John Harwood Scott, Matthew Gordon, Robert Vender, Samantha Pettigrew, Parag Desai, Nathaniel Marchetti, Albert James Mamary, Joseph Panaro, Gary Cohen, Riyaz Bashir, Vladimir Lakhter, Stephanie Roth, Huaqing Zhao, Yoshiya Toyoda, Gerard Criner, Lisa Moores, Parth Rali
Affiliations expand
PMID: 33590996
DOI: 10.1097/CCM.0000000000004828