PERTinent Updates:
Issue 29


Issue 29

Welcome to issue 29 of PERTinent Updates, featuring a select group of articles for your review. We aim to inform and update our members with the most recent major developments in the fields of PERT/VTE so that we in the PERT Consortium® can continue to be at the leading edge of improving care for this vulnerable and overlooked group of patients.



Recent Guidelines

Prevention, diagnosis and treatment of venous thromboembolism in patients with COVID-19: CHEST Guideline and Expert Panel Report
Moores LK, Tritschler T, Brosnahan S, Carrier M, Collen JF, Doerschug K, Holley AB, Jimenez D, Legal G, Rali P, Wells, P. PII: S0012-3692(20)31625-1


Scientific and Standardization Committee Communication: Clinical Guidance on the Diagnosis, Prevention and Treatment of Venous Thromboembolism in Hospitalized Patients with COVID-19.
Spyropoulos AC, Levy JH, Ageno W, Connors JM, Hunt BJ, Iba T, Levi M, Samama CM, Thachil J, Giannis D, Douketis JD; Subcommittee on Perioperative, Critical Care Thrombosis, Haemostasis of the Scientific, Standardization Committee of the International Society on Thrombosis, Haemostasis+.J Thromb Haemost. 2020 May 27. doi: 10.1111/jth.14929. Online ahead of print.
PMID: 32459046


Thromboembolism and anticoagulant therapy during the COVID-19 pandemic: interim clinical guidance from the anticoagulation forum.
Barnes GD, Burnett A, Allen A, Blumenstein M, Clark NP, Cuker A, Dager WE, Deitelzweig SB, Ellsworth S, Garcia D, Kaatz S, Minichiello T.J Thromb Thrombolysis. 2020 Jul;50(1):72-81.
doi: 10.1007/s11239-020-02138-z.
PMID: 32440883



VTE and COVID-19

COVID and Coagulation: Bleeding and Thrombotic Manifestations of SARS-CoV2 Infection.
Al-Samkari H, Karp Leaf RS, Dzik WH, Carlson JC, Fogerty AE, Waheed A, Goodarzi K, Bendapudi P, Bornikova L, Gupta S, Leaf D, Kuter DJ, Rosovsky RP.Blood. 2020 Jun 3:blood.2020006520. doi: 10.1182/blood.2020006520.
Online ahead of print.PMID: 32492712


Anti-Coagulant and Anti-Platelet Therapy in the COVID-19 Patient: A Best Practices Quality Initiative Across a Large Health System.
Watson RA, Johnson DM, Dharia RN, Merli GJ, Doherty JU.Hosp Pract (1995). 2020 May 19. doi: 10.1080/21548331.2020.1772639. Online ahead of print.
PMID: 32429774


COVID-19 and its implications for thrombosis and anticoagulation.
Connors JM, Levy JH. Blood. 2020 Apr 27. pii: blood.2020006000. doi: 10.1182/blood.2020006000. [Epub ahead of print]
PMID: 32339221


Catheter-directed thrombolysis in COVID-19 pneumonia with acute PE: Thinking beyond the guidelines.
Qanadli SD, Gudmundsson L, Rotzinger DC.Thromb Res. 2020 May 8;192:9-11. doi: 10.1016/j.thromres.2020.05.007.
Online ahead of print.
PMID: 32416366



VTE Preventions

Call to Action to Prevent Venous Thromboembolism in Hospitalized Patients: A Policy Statement From the American Heart Association.
Henke PK, Kahn SR, Pannucci CJ, Secemksy EA, Evans NS, Khorana AA, Creager MA, Pradhan AD; American Heart Association Advocacy Coordinating Committee. Circulation. 2020 May 7:CIR0000000000000769. doi: 10.1161/CIR.0000000000000769.
[Epub ahead of print] PMID: 32375490
[PubMed – as supplied by publisher]



PE Response Team (PERT)

Changes in Care for Acute Pulmonary Embolism with a Multidisciplinary Pulmonary Embolism Response Team: PE Response Team.
Carroll BJ, Beyer SE, Mehegan T, Dicks A, Pribish A, Locke A, Godishala A, Soriano K, Kanduri J, Sack K, Raber I, Wiest C, Balachandran I, Marcus M, Chu L, Hayes MM, Weinstein JL, Bauer KA, Secemsky EA, Pinto DS.Am J Med. 2020 May 13:S0002-9343(20)30374-0. doi: 10.1016/j.amjmed.2020.03.058. Online ahead of print.
PMID: 32416175



PE Treatment

Association Between Reperfusion Therapy and Outcomes in Patients with Acute Pulmonary Embolism and Right Heart Thrombi.
Bikdeli B, Jiménez D, Muriel A, Barrios D, Ballaz A, Verhamme P, Monreal M; RIETE Investigators.Eur Respir J. 2020 May 19:2000538. doi: 10.1183/13993003.00538-2020. Online ahead of print.
PMID: 32430430



From Our Own

State of the Art: Contemporary Management of Acute Pulmonary Embolism.
Tan CW, Balla S, Ghanta RK, Sharma AM, Chatterjee S. Semin Thorac Cardiovasc Surg. 2020 Apr 27. pii: S1043-0679(20)30111-8. doi: 10.1053/j.semtcvs.2020.04.002.[Epub ahead of print]
PMID: 32353408
[PubMed – as supplied by publisher]


Extended Venous Thromboembolism Prophylaxis in Medically Ill Patients: An NATF Anticoagulation Action Initiative.
Barkoudah E, Piazza G, Hecht TEH, Grant P, Deitelzweig S, Fang MC, Fanikos J, Kao CK, Barnes GD, Chen T, Ramishvili T, Schnipper JL, Goldstein JN, Ruff CT, Kaatz S, Schwartz A, Connors JM, Goldhaber SZ. Am J Med. 2020 May;133 Suppl 1:1-27. doi: 10.1016/j.amjmed.2019.12.001.
PMID: 32362349


Predictors of Not Initiating Anticoagulation After Incident Venous Thromboembolism: A Danish Nationwide Cohort Study.
Albertsen IE, Goldhaber SZ, Piazza G, Overvad TF, Nielsen PB, Larsen TB, Søgaard M. Am J Med. 2020 Apr;133(4):463-472.e5. doi: 10.1016/j.amjmed.2019.08.051. Epub 2019 Oct 10.
PMID: 31606490


Predictors of Treatment Response Following Ultrasound-Facilitated Catheter-Directed Thrombolysis for Submassive and Massive Pulmonary Embolism: A SEATTLE II Substudy
Sardar, P., Piazza, G., Goldhaber, S. Z., Liu, P. Y., Prabhu, W., Soukas, P., & Aronow, H. D. (2020).. Circulation. Cardiovascular interventions, 13(6), e008747.