PERTinent Updates:
Issue 24

Welcome to issue 24 of PERTinent Updates, featuring a select group of articles for your review. We aim to inform and update our members with the most recent major developments in the fields of PERT/VTE so that we in the PERT Consortium™ can continue to be at the leading edge of improving care for this vulnerable and overlooked group of patients.




American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients.
Anderson DR, Morgano GP, Bennett C, Dentali F, Francis CW, Garcia DA, Kahn SR, Rahman M, Rajasekhar A, Rogers FB, Smythe MA, Tikkinen KAO, Yates AJ, Baldeh T, Balduzzi S, Brożek JL, Ikobaltzeta IE, Johal H, Neumann I, Wiercioch W, Yepes-Nuñez JJ, Schünemann HJ, Dahm P.
Blood Adv. 2019 Dec 10;3(23):3898-3944. doi: 10.1182/bloodadvances.2019000975



Risk Stratification

Diagnosis of Pulmonary Embolism with d-Dimer Adjusted to Clinical Probability.
Kearon C, de Wit K, Parpia S, Schulman S, Afilalo M, Hirsch A, Spencer FA, Sharma S, D’Aragon F, Deshaies JF, Le Gal G, Lazo-Langner A, Wu C, Rudd-Scott L, Bates SM, Julian JA; PEGeD Study Investigators.
N Engl J Med. 2019 Nov 28;381(22):2125-2134.
PMID: 31774957

Systolic blood pressure and mortality in acute symptomatic pulmonary embolism.
Quezada A, Jiménez D, Bikdeli B, Moores L, Porres-Aguilar M, Aramberri M, Lima J, Ballaz A, Yusen RD, Monreal M; RIETE investigators.
Int J Cardiol. 2019 Nov 14. pii: S0167-5273(19)31944-8. [Epub ahead of print]
PMID: 31761399PMID: 31744599




Effect of Statins on Recurrent Venous Thromboembolism (from the COMMAND VTE Registry).
Yoshikawa Y, Yamashita Y, Morimoto T, Mabuchi H, Amano H, Takase T, Hiramori S, Kim K, Oi M, Akao M, Kobayashi Y, Toyofuku M, Izumi T, Tada T, Chen PM, Murata K, Tsuyuki Y, Saga S, Nishimoto Y, Sasa T, Sakamoto J, Kinoshita M, Togi K, Takabayashi K, Shiomi H, Kato T, Makiyama T, Ono K, Murakami T, Kimura T; COMMAND VTE Registry Investigators.
Am J Cardiol. 2020 Jan 15;125(2):189-197. Epub 2019 Oct 30.
PMID: 31744599




Need for Transthoracic Echocardiogram in Patients with Low-Risk Pulmonary Thromboembolism: A Systematic Review and Meta-Analysis.
Andrade I, García A, Mercedes E, León F, Velasco D, Rodríguez C, Pintado B, Pérez A, Jiménez D.
Arch Bronconeumol. 2019 Nov 26. pii: S0300-2896(19)30396-5. doi: 10.1016/j.arbres.2019.08.025. [Epub ahead of print] English, Spanish.
PMID: 31784347



Upcoming Studies

Validation and impact of a simplified clinical decision rule for diagnosing pulmonary embolism in primary care: design of the PECAN prospective diagnostic cohort management study.
van Maanen R, Rutten FH, Klok FA, Huisman MV, Blom JW, Moons KGM, Geersing GJ.
BMJ Open. 2019 Oct 10;9(10):e031639. doi: 10.1136/bmjopen-2019-031639.
PMID: 31601598


Additionally, there is a non-peer reviewed supplement from European Heart Journal sponsored by BTG focused on catheter directed therapy for pulmonary embolism.



From Our Own…

Clinical outcomes of inferior vena cava filter in complicated pulmonary embolism.
Gul MH, Htun ZM, Rigdon J, Rivera-Lebron B, Perez VJ.
Pulm Circ. 2019 Nov 20;9(4):2045894019882636. eCollection 2019 Oct-Dec.
PMID: 31798833


Dyspnea Post Pulmonary Embolism from VD/VT and Stroke Volume Defects During Exercise.
Fernandes TM, Alotaibi M, Strozza D, Stringer W, Porszasz J, Faulkner G, Castro C, Tran D, Morris TA.
Chest. 2019 Nov 21. pii: S0012-3692(19)34219-9. [Epub ahead of print]
PMID: 31759962


Low left ventricular outflow tract velocity time integral is associated with poor outcomes in acute pulmonary embolism.
Yuriditsky E, Mitchell OJ, Sibley RA, Xia Y, Sista AK, Zhong J, Moore WH, Amoroso NE, Goldenberg RM, Smith DE, Jamin C, Brosnahan SB, Maldonado TS, Horowitz JM.
Vasc Med. 2019 Nov 10:1358863X19880268. [Epub ahead of print]
PMID: 31709912


Outcome Measures for Acute Submassive Pulmonary Embolisms at a Community-Based Hospital Using Ultrasound-Facilitated, Catheter-Directed, Low-Dose Fibrinolysis.
Hooks B, Sharma V, Taylor G, Wadhwani S, Ehtesham M.
Vasc Endovascular Surg. 2019 Nov 26:1538574419885275 [Epub ahead of print]
PMID: 31769352


Reduced dose thrombolysis with ultrasound-facilitated catheter-directed administration for acute pulmonary embolism reduces length of stay.
Wayne NB, Davis GA, Macaulay TE, Beavers CJ, Messerli AW, Dugan A, Smyth SS. J Thromb Thrombolysis. 2019 Dec 3. [Epub ahead of print]
PMID: 31797241


Right Ventricular Outflow Doppler Predicts Low Cardiac Index in Intermediate Risk Pulmonary Embolism.
Brailovsky Y, Lakhter V, Weinberg I, Porcaro K, Haines J, Morris S, Masic D, Mancl E, Bashir R, Alkhouli M, Rosenfield K, Mathew V, Lopez J, Bechara CF, Joyce C, Fareed J, Darki A.
Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029619886062.
PMID: 31722539


Utilization and Outcomes of Thr­ombolytic Therapy for Acute Pulmonary Embolism: A Nationwide Cohort Study.
Beyer SE, Shanafelt C, Pinto DS, Weinstein JL, Aronow HD, Weinberg I, Yeh RW, Secemsky EA, Carroll BJ.
Chest. 2019 Nov 26. pii: S0012-3692(19)34284-9. [Epub ahead of print]
PMID: 31783016