Thrombolytic Therapy for Pulmonary Embolism (full and half dose)

Impact of Thrombolytic Therapy on the Long-Term Outcome of Intermediate-Risk Pulmonary Embolism.

Konstantinides SV, Vicaut E, Danays T, Becattini C, Bertoletti L, Beyer-Westendorf J, Bouvaist H, Couturaud F, Dellas C, Duerschmied D, Empen K, Ferrari E, Galiè N, Jiménez D, Kostrubiec M, Kozak M, Kupatt C, Lang IM, Lankeit M, Meneveau N, Palazzini M, Pruszczyk P, Rugolotto M, Salvi A, Sanchez O, Schellong S, Sobkowicz B, Meyer G.

J Am Coll Cardiol. 2017 Mar 28;69(12):1536-1544. doi: 10.1016/j.jacc.2016.12.039.

PMID: 28335835

Therapeutic Fibrinolysis: How Efficacy and Safety Can Be Improved.

Gurewich V.

J Am Coll Cardiol. 2016 Nov 8;68(19):2099-2106. doi: 10.1016/j.jacc.2016.07.780. Review.

PMID: 27810050

Pulmonary Embolism with Right Ventricular Dysfunction: Who Should Receive Thrombolytic Agents?

Desai H, Natt B, Bime C, Dill J, Dalen JE, Alpert JS.

Am J Med. 2017 Jan;130(1):93.e29-93.e32. doi: 10.1016/j.amjmed.2016.07.023. Epub 2016 Aug 24.

PMID: 27566503

Acute Pulmonary Embolism: With an Emphasis on an Interventional Approach.

Jaber WA, Fong PP, Weisz G, Lattouf O, Jenkins J, Rosenfield K, Rab T, Ramee S.

J Am Coll Cardiol. 2016 Mar 1;67(8):991-1002. doi: 10.1016/j.jacc.2015.12.024. Review.

PMID: 26916490

Antithrombotic Therapy for VTE Disease: CHEST Guideline and Expert Panel Report.

Kearon C, Akl EA, Ornelas J, Blaivas A, Jimenez D, Bounameaux H, Huisman M, King CS, Morris TA, Sood N, Stevens SM, Vintch JRE, Wells P, Woller SC, Moores L.

Chest. 2016 Feb;149(2):315-352. doi: 10.1016/j.chest.2015.11.026. Epub 2016 Jan 7.

PMID: 26867832

The role of thrombolytic therapy in pulmonary embolism.

Wang TF, Squizzato A, Dentali F, Ageno W.

Blood. 2015 Apr 2;125(14):2191-9. doi: 10.1182/blood-2014-08-559278. Epub 2015 Jan 28. Review. No abstract available.

PMID: 25631770

2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism.

Konstantinides SV, Torbicki A, Agnelli G, Danchin N, Fitzmaurice D, Galiè N, Gibbs JS, Huisman MV, Humbert M, Kucher N, Lang I, Lankeit M, Lekakis J, Maack C, Mayer E, Meneveau N, Perrier A, Pruszczyk P, Rasmussen LH, Schindler TH, Svitil P, Vonk Noordegraaf A, Zamorano JL, Zompatori M; Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC).

Eur Heart J. 2014 Nov 14;35(43):3033-69, 3069a-3069k. doi: 10.1093/eurheartj/ehu283. Epub 2014 Aug 29. No abstract available. Erratum in: Eur Heart J. 2015 Oct 14;36(39):2666Eur Heart J. 2015 Oct 14;36(39):2642.

PMID:  25173341

Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta-analysis.

Chatterjee S, Chakraborty A, Weinberg I, Kadakia M, Wilensky RL, Sardar P, Kumbhani DJ, Mukherjee D, Jaff MR, Giri J.

JAMA. 2014 Jun 18;311(23):2414-21. doi: 10.1001/jama.2014.5990.

PMID: 24938564

Fibrinolysis for patients with intermediate-risk pulmonary embolism.

Meyer G, Vicaut E, Danays T, Agnelli G, Becattini C, Beyer-Westendorf J, Bluhmki E, Bouvaist H, Brenner B, Couturaud F, Dellas C, Empen K, Franca A, Galiè N, Geibel A, Goldhaber SZ, Jimenez D, Kozak M, Kupatt C, Kucher N, Lang IM, Lankeit M, Meneveau N, Pacouret G, Palazzini M, Petris A, Pruszczyk P, Rugolotto M, Salvi A, Schellong S, Sebbane M, Sobkowicz B, Stefanovic BS, Thiele H, Torbicki A, Verschuren F, Konstantinides SV; PEITHO Investigators.

N Engl J Med. 2014 Apr 10;370(15):1402-11. doi: 10.1056/NEJMoa1302097.

PMID: 24716681

Treatment of submassive pulmonary embolism with tenecteplase or placebo: cardiopulmonary outcomes at 3 months: multicenter double-blind, placebo-controlled randomized trial.

Kline JA, Nordenholz KE, Courtney DM, Kabrhel C, Jones AE, Rondina MT, Diercks DB, Klinger JR, Hernandez J.

J Thromb Haemost. 2014 Apr;12(4):459-68. doi: 10.1111/jth.12521.

PMID: 24484241

Lower dosage of recombinant tissue-type plasminogen activator (rt-PA) in the treatment of acute pulmonary embolism: a systematic review and meta-analysis.

Zhang Z, Zhai ZG, Liang LR, Liu FF, Yang YH, Wang C.

Thromb Res. 2014 Mar;133(3):357-63. doi: 10.1016/j.thromres.2013.12.026. Epub 2013 Dec 23. Review.

PMID: 24412030

Moderate pulmonary embolism treated with thrombolysis (from the “MOPETT” Trial).

Sharifi M, Bay C, Skrocki L, Rahimi F, Mehdipour M; “MOPETT” Investigators.

Am J Cardiol. 2013 Jan 15;111(2):273-7. doi: 10.1016/j.amjcard.2012.09.027. Epub 2012 Oct 24.

PMID: 23102885

Thrombolytic therapy in unstable patients with acute pulmonary embolism: saves lives but underused.

Stein PD, Matta F.

Am J Med. 2012 May;125(5):465-70. doi: 10.1016/j.amjmed.2011.10.015. Epub 2012 Feb 10. Erratum in: Am J Med. 2012 Jul;125(7):e13.

PMID: 22325236

Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association.

Jaff MR, McMurtry MS, Archer SL, Cushman M, Goldenberg N, Goldhaber SZ, Jenkins JS, Kline JA, Michaels AD, Thistlethwaite P, Vedantham S, White RJ, Zierler BK; American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; American Heart Association Council on Peripheral Vascular Disease; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology.

Circulation. 2011 Apr 26;123(16):1788-830. doi: 10.1161/CIR.0b013e318214914f. Epub 2011 Mar 21. Erratum in: Circulation. 2012 Aug 14;126(7):e104. Circulation. 2012 Mar 20;125(11):e495.

PMID: 21422387

Thrombolytic therapy for acute pulmonary embolism: a critical appraisal.

Todd JL, Tapson VF.

Chest. 2009 May;135(5):1321-1329. doi: 10.1378/chest.08-2125. Review.

PMID: 19420199