Welcome to the twelfth monthly email of PERTinent Updates featuring a select group of articles for your review. We aim to inform and update our members with the most recent major developments in the fields of PERT/VTE so that we in the PERT Consortium can continue to be at the leading edge of improving care for this vulnerable and overlooked group of patients.

This month’s “From Our Own” section features articles by Belinda Rivera-Lebron, Catalin Toma, Efthymios Avgerinos, Rabih Chaer and Robert Maholic in Journal of Vascular Surgery: Venous and Lymphatic Disorders; Blair Parry, Christopher Kabrhel and Nicholas Giordano in  Academic Emergency Medicine; Eric Bondarsky, Jason Filopei, Moynul Islam, Navitha Ramesh and David Steiger in Respirology.

Statistical analysis plan for the Pneumatic CompREssion for PreVENting Venous Thromboembolism (PREVENT) trial: a study protocol for a randomized controlled trial, is featured in “Upcoming Studies”. The Pneumatic CompREssion for Preventing VENous Thromboembolism (PREVENT) trial evaluates the effect of adjunctive intermittent pneumatic compression (IPC) with pharmacologic thromboprophylaxis compared to pharmacologic thromboprophylaxis alone on venous thromboembolism (VTE) in critically ill adults.

Risk Stratification

Clinical relevance of syncope in patients with pulmonary embolism.
Lee YH, Cha SI, Shin KM, Lim JK, Yoo SS, Lee SY, Lee J, Kim CH, Park JY, Lee WK. Thromb Res. 2018 Mar 2;164:85-89. [Epub ahead of print] PMID: 29522911

Performance of Early Prognostic Assessment Independently Predicts the Outcomes in Patients with Acute Pulmonary Embolism.
Barbero E, Bikdeli B, Chiluiza D, Barrios D, Morillo R, Quezada A, Monreal M, Yusen RD, Jimenez D. Thromb Haemost. 2018 Mar 19. [Epub ahead of print] PMID: 29554702

Treatment

Peripheral Distribution of Thrombus Does Not Affect Outcomes After Surgical Pulmonary Embolectomy.
Pasrija C, Shah A, George P, Mohammed I, Brigante FA, Ghoreishi M, Jeudy J, Taylor BS, Gammie JS, Griffith BP, Kon ZN. Ann Thorac Surg. 2018 Apr 4. pii: S0003-4975(18)30420-X. [Epub ahead of print] PMID: 29626452

IVC Filters

Rising Retrieval Rates of Inferior Vena Cava Filters in the United States: Insights From the 2012 to 2016 Summary Medicare Claims Data.
Ahmed O, Wadhwa V, Patel K, Patel MV, Turba UC, Arslan B. J Am Coll Radiol. 2018 Mar 30. pii: S1546-1440(18)30161-3. [Epub ahead of print] PMID: 29606636

CTEPH

Chronic thromboembolic pulmonary hypertension from the perspective of patients with pulmonary embolism.
Klok FA, Delcroix M, Bogaard HJ. J Thromb Haemost. 2018 2018 Apr 2. doi: 10.1111/jth.14016. [Epub ahead of print] Review. PMID: 29608809

Upcoming Trial

Statistical analysis plan for the Pneumatic CompREssion for PreVENting Venous Thromboembolism (PREVENT) trial: a study protocol for a randomized controlled trial.
Arabi Y, Al-Hameed F, Burns KEA, Mehta S, Alsolamy S, Almaani M, Mandourah Y, Almekhlafi GA, Al Bshabshe A, Finfer S, Alshahrani M, Khalid I, Mehta Y, Gaur A, Hawa H, Buscher H, Arshad Z, Lababidi H, Al Aithan A, Jose J, Abdukahil SAI, Afesh LY, Dbsawy M, Al-Dawood A; PREVENT trial Group. Trials. 2018 Mar 15;19(1):182. doi: 10.1186/s13063-018-2534-6. PMID: 29544550 [PubMed – in process]

From Our Own…

Catheter-directed interventions compared with systemic thrombolysis achieve improved ventricular function recovery at a potentially lower complication rate for acute pulmonary embolism.
Avgerinos ED, Abou Ali AN, Liang NL, Rivera-Lebron B, Toma C, Maholic R, Makaroun MS, Chaer RA. J Vasc Surg Venous Lymphat Disord. 2018 Mar 31. pii: S2213-333X(18)30067-2. [Epub ahead of print] PMID: 29615372

Multicenter Evaluation of the YEARS Criteria in Emergency Department Patients Evaluated for Pulmonary Embolism.
Kabrhel C, Van Hylckama Vlieg A, Muz ikanski A, Singer A, Fermann GJ, Francis S, Lim Kakeng A, Chang AM, Giordano N, Parry B. Acad Emerg Med. 2018 Mar 31. [Epub ahead of print] PMID: 29603819

Pulmonary infarction secondary to pulmonary embolism: An evolving paradigm
Islam M, Filopei J, Frank M, Ramesh N, Verzosa S, Ehrlich M, Bondarsky E, Miller A, Steiger D. Respirology. 2018 Mar 25. PMID 29577524